Both hormone replacement therapy (HRT) and
soy isoflavones have an estrogenic stimulating effect on the beta receptors controlling
the brain, bones, blood vessels and lipoproteins. However, hormone replacement therapy (HRT) also has an estrogenic stimulating
effect on the alpha receptors controlling the breasts and uterus, whereas
soy isoflavones main
components of Daidzein and Genistein have an anti-estrogenic effect.
This means that
soy isoflavones are
"Selective Estrogen Receptor Modulators" (SERM), and have the
ability to target the symptoms of menopause without causing rogue cell growth in the vital areas of
the breasts and uterus.
The pan-European study conducted by Palacios et al. aimed to assess the effect of long term use
(3 years) of an oral soy isoflavone
on the endometrium and the
breasts. This would assess
whether or not the natural
extract carried risks of accelerated cell growth in the
breasts and uterus.
The results showed long term harmlessness of 70mg of
Phyto Soya on the breast and endometrium. The
results of these studies are only applicable to the standardised specific extract in
rich in Daidzein.
Directions for Use:
For less than 8 flushes per day:
Use Phyto Soya Regular (17.5mg twice a day - morning and evening)
For severe cases (more than 8 flushes per day):
Use Phyto Soya Double Potency (35mg twice a day - morning and evening)
Isoflavones leave the body after 8 - 10 hours so it is important to take the
capsule twice a day, morning and evening, to maintain the balance over 24 hours.
Also in the range is Phyto Soya Moisturising and Lubricating Vaginal Gel.
The Impact of Menopause
A decrease in libido which is accompanied by drier vaginal mucous membranes.
This causes vaginal dryness which can interfere with sexual relations and make
women more susceptible to bladder infections.
A tenderness of the breasts in not uncommon as is the appearance of lumps and cysts.
To combat anxiety and the fear of cancer, regular mammograms and ultrasound are recommended.
Anxiety is a feeling of restlessness, uneasiness and fear of something
intangible, that you cannot quite put your finger on, often accompanied by sleeplessness
Mood swings are often triggered by anxiety, where feelings of
happiness are followed by a sudden change to sadness or depression. Mood swings
are often the result of hormonal imbalance or an unhealthy lifestyle.
Hot flushes, also called ‘hot flashes’ are feelings of being extremely
hot and perspiring for a minute or 2 at a time. Hot flushes can be brought on by
stressful situations, but some women suffer from them throughout the day during
menopause and often into the night, resulting in night sweats.
Night sweats lead to restless nights and sleep disruptions for many menopausal women resulting in fatigue and irritability the following day.
The renewal of bone tissue is a process dependent on hormones.
When bone tissue begins to weaken and lose its strength, it bonds less with calcium.
The loss of bone density can precipitate osteoporosis, a serious condition that
increases the risk of bone fractures. It affects one in three women after 50 and
one in ten men.
A risk of developing cardiovascular disease. These risks increase with
cholesterol levels, blood pressure, blood sugar and homocysteine levels,
weight, tobacco use, sedentary lifestyle, stress and an excess of refined
sugar and fat. Whilst the best preventative strategy is a healthy lifestyle
that combines a balanced diet with exercise and relaxation, studies carried
out on animals and humans demonstrate that isoflavones also help decrease the
risk of cardiovascular diseases.
Dr Michèle Serrand (a French medical doctor and writer) notes from studies that
Japanese women living in their home country rarely suffer from hot flushes and
the incidence of osteoporosis among them is much reduced - in fact, research showed
that Japanese women have a fracture risk 40% lower than American women. Moreover,
they have far less cardiovascular disease and breast cancer. Researchers have shown
that this advantage is linked to their diet, particularly the presence of soya at
Stages of Menopause
Symptoms of the onset of menopause are due in part to the decrease in the
hormone levels of estrogen and are manifested in hot flushes and night sweats.
The frequency and severity varies from one woman to the next. Stress,
fatigue and nervousness aggravate this phenomenon, as does the consumption
of alcohol, coffee, spices and tobacco. The drop in estrogen levels makes room
for the male hormones secreted by the adrenals. This explains the possible loss
of hair on the head and the appearance of hair, especially on the top lip.
Also, skin loses its elasticity and thins to form more lines and wrinkles.
Pre-menopause is the time before the definitive end of menstruation. During
this stage, menstruation becomes erratic. This time period varies from 6 months
to 10 years and begins on average at the age of 48.
Peri-menopause is the period of time that includes pre-menopause and the year
following the end of menstruation.
Menopause is the definitive end of menstrual periods and is determined by the
cessation of periods for at least one year.
Many women opt for
HRT for its aesthetic and specific health benefits (though
it’s also not without its risks), while others prefer to use natural remedies
to get them through the change of life. By combining a natural soya-based
supplement with exercise and an appropriate diet, the risk of experiencing heart
and bone problems is also reduced.
Phytoestrogens used by Arkopharma
Plants naturally produce substances that mimic estrogens when ingested.
Called phytoestrogens or plant estrogens, these molecules hold a special
place in the therapeutic arsenal of
menopause. In the 1950’s, two of the
substances that belong to the isoflavone family, genistein and daidzein,
were isolated by scientists. A great many plants, including clover and
soya, synthesise these substances.
Phyto Soya by
extracts of soya hypocotyls which have the highest concentration of daidzein.
Soy isoflavones are transformed into genistein and daidzein by intestinal
bacteria. These have shown to produce an estrogenic effect (i.e. having a
similar effect of estrogen) on brain, bone, lung, vessel and bladder tissues
while exhibiting an anti-estrogenic effect (i.e. inhibits estrogenic activity)
on ovaries, breasts and the uterus.
SOYA is also a rich source of protein and omega-3 unsaturated fatty acids and
it comes in many forms. Soya beans can be prepared and used as one would lentils
and peas or they can be converted into soya milk, tofu, miso, tempeh, soya
sauce and tamari.
ARKOPHARMA are experts in menopause and their research on Phyto Soya
has established with certainty:
1. The efficacy and tolerance of the product for treatment of disorders related to menopause.
2. The validity of the dosage.
3. The daidzein-genistein balance of the formula.
This highlights the importance of selecting products that have undergone serious clinical studies
and which have been published in medical journals. To view the studies, visit www.phytosoya.com
of PHYTO SOYA by ARKOPHARMA
61% reduction in hot flushes in 4 weeks. Published in Menopause 2002, a clinical study done at a
dose of 70mg isoflavones (Phyto Soya High Strength) per day on 75 menopausal women for 4 months.
(Drapier, Faure, Chantre, Mares)
80.2% reduction in hot flushes, night sweats, anxiety and depression in 4 weeks. Published in
Phytomedicine 2002, a clinical study done at a dose of 35mg isoflavones (Phyto Soya Regular) per
day on 190 menopausal women for 4 months. (Albert, Altabre, et al)
Improvement in quality of life with significant relief from symptoms. Published in Menopause 2007
and Climacteric 2008, clinical studies done at a dose of 70mg isoflavones (Phyto Soya High Strength)
on 305 menopausal women for 12 months. (Palacios, et al)
Endometrial and breast safety. Published in Climacteric 2010, a clinical study done at a dose of
70mg isoflavones (Phyto Soya High Strength) on 197 women and 395 post-menopausal women over 3 years.
(Palacios, Pornel, Vazquez, et al)
New Research supports Soy Isoflavones efficacy in bone density:
The prevalence of age-related bone loss is higher in women than in men, and in 25% to 30% of
ageing women, this loss results in major orthopedic problems.
The ovarian hormone deficiency associated with
menopause, results in increased rate of bone turnover and imbalance between resorption (disintegration) and
formation, and thereby accelerates bone loss.
In march 2012, a new meta-analysis published in Asia (2), shows clearly that
soy isoflavones significantly
increased bone mineral density and decreased the bone resorption market.
This represents a complementary
and fundamental support to promote
soy isoflavones to menopausal women.
UK campaign for natural menopause treatments on the NHS:
A nationwide survey conducted in the UK
as part of a campaign for proven
natural menopause treatments to be available on the NHS revealed that
80% of menopausal women in the UK are not being offered
alternatives to HRT.